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Auteurs
Zhang
M-B, Ji-Liang H, Li-Fen J, De-Qiang L (2002):
The aim of this
study was to determine if exposure to radiofrequency radiation (RFR)
had a synergistic effect with Mitomycin C (MMC) in the production of
DNA damage in blood lymphocytes. MMC is a drug used in the treatment
of cancer that is known to produce DNA damage.
Blood from one male
and one female donor was divided into 10 groups:
-
control group;
-
Microwave radiation (MW) group - the blood was exposed to 2450 MHz
frequency at 5.0 mW/cm² for 2 hours;
-
Ffour MMC groups
- the blood was exposed to MMC for 24 hours at concentrations 0.0125
µg/ml, 0.025 µg/ml, 0.05 µg/ml, and 0.1 µg/ml
respectively;
- MW plus MMC groups
- the blood was first exposed to MW for 2 hours and then treated with
MMC for 24 hours in the same concentrations. DNA damage was estimated
by the comet test, and the lymphocytes were examined for micronuclei,
an indication of chromosomal damage.
While the MW exposure
did not produce any evidence of DNA or chromosomal damage, the MW+MMC
groups showed significantly longer comet lengths than the MMC groups
when the concentrations of MMC were 0.025 µg/ml or greater. However,
the number of micronuclei was not significantly greater in the MW+MMC
groups, compared to the MMC groups alone.
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