Sanchez S, Masuda H, Ruffie G, Poulletier
De Gannes F, et al. (2007b)
The aim of this study was to test the effect of
RFR exposure on the expression of HSPs in the skin of hairless
rats. Two sets of experiments were done. In the first, the right
part of the rat's back was exposed or sham-exposed to RFR at 5
W/kg for 2 hours, and the animals were then immediately sacrificed
and a skin biopsy taken. In the second experiment, the rats were
exposed or sham-exposed at 2.5 or 5 W/kg for 2 hours a day, 5 days
per week, for 12 weeks. Skin biopsies were taken within 72 hours
of the last exposure.
For both sets of experiments eight animals were in each of 4 groups
- cage-controls, sham-exposed, GSM-900 exposure, and GSM-1800 exposure.
Two other animals were exposed to UVB radiation (400 mJ/cm²)
and skin samples taken 24 hours, for positive control purposes.
Neither single nor repeated exposures altered HSP
expression in rat skin. The HSPs examined were Heat-shock cognate
70, and HSP 25 and 70.