Kuribayashi M, Wang J, Fujiwara O, Doi Y, et al. (2005)

The authors conducted experiments in immature and young adult rats to test the effects of exposure to radiofrequency radiation (RFR) on the blood-brain barrier (BBB). They reasoned that rats at this age would be more susceptible to the effects of RFR exposure.

The authors examined levels of genes that encode 3 proteins that are involved in the structural integrity of the BBB. They also tested for vascular permeability in to brain tissues by using the tracer FITC-dextran, labeled with a fluorescein dye.

As a positive control experiment, immature rats were injected intraperitoneally with 1,3-dinitrobenzene. This substance, which is thought to disrupt the BBB, was associated with a decrease in the three genes and with transfer of the dextran.

In the RFR experiment, rats at the age of 4 (immature) and 10 (young adults) weeks were exposed to RFR at 1439 MHz (SAR brain-average 0, 2, and 6 W/kg) for 90 minutes a day for 6 days per week over 1 or2 weeks. There was no effect on the expression of the genes or on dextran permeability.

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