Höytö A, Juutilainen J, Naarala J (2007).

Murine L929 fibroblasts, rat C6 glioblastoma cells, human SH-SY5Y neuroblastoma cells and rat primary astrocytes were exposed to RFR at 872 MHz. The cells were exposed for 2,8, or 24 hours to continuous wave (CW) RFR or to a GSM type signal pulse modulated at 217 Hz, at SARs of 1.5, 2.5, or 6.0 W/kg (except in the case of the primary astrocytes, which were not exposed at 2.5 W/kg). Cellular ODC levels were determined.

ODC activity was reduced in primary astrocytes at a statistically significant level, at both 1.5 and 6.0 W/kg SAR, and in both CW and GSM modulated exposure. In the secondary cell lines ODC activity was generally unaffected, except in two instances that may have been related to accidental temperature increase in the cell medium.

The authors point out that decrease in ODC activity leads to impaired polyamine synthesis, which results in decreased proliferation.


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