Buttiglione M, Roca L, Montemurno E, Vitiello F, et al. (2007):
Egr-1 is a gene essential for proliferation, differentiation,
and apoptosis. Buttiglione and colleagues studied the effect of
RFR exposure on Egr-1 activation by exposing human neuroblastoma
cells to RFR at 900 MHz frequency, or to sham exposure, for 5,
15, 30 minutes, and 6 and 24 hours. The SAR was 1 W/kg.
RFR exposure activated Egr-1 within 5 minutes, reaching a peak
at 15 minutes. At 6 hours the effect was no longer apparent. There
were parallel effects on mitogen-activated protein kinases (MAPK)
that are involved in the activation of Egr-1. Exposure to RFR had
an anti-proliferative effect on the cells, with a significant effect
at 24 hours, and also impaired cell cycle progression.