W, Jiliang H, Lifen J, Deqiang L, et al. (2005)
This study was
designed to assess the effect of radiofrequency radiation (RFR)
on human lymphocytes, with and without chemical mutagens. Four chemicals
were used – mitomycin C (MMC), 4-nitroquinoline-1-oxide (4NQO),
bleomycin, (BLM), and methyl methanesulfonate (MMS).
The lymphocytes were exposed to RFR for 2 hours and to the chemical
for 3 hours. The RFR was administered before, at the same time,
or after the administration of the chemical mutagen. Four different
strengths of each chemical were used in different experiments. The
SAR of the RFR was 3 W/kg. DNA damage was assessed by the comet
assay. The assay was assessed at 0 and 21 hours.
There was no difference in DNA damage indexes between the control
group and the RFR group. However, there were significant differences
between the MMC group and the MMC+RFR group at 0 and 21 hours incubation,
and between the 4NQO group and the 4NQO+RFR group. These results
were seen in all situations where RFR was administered, independent
of its timing with respect to the chemical mutagen administration.
The other two chemical mutagens did not show synergistic effects
with the RFR.