Ayata A, Mollaoglu H, Yilmaz HR, Akturk O, et al. (2004)
In this study 30 Wistar-albino rats were used. Ten were used as controls, 10 were irradiated with 900 MHz for 30 minutes a day for 10 days at 2 W (power density 1±0.4 mW/cm²), and 10 were similarly irradiated but were also given melatonin (10mg/kg/day) for 10 days before the radiation. The rats were only 5 mm away from the dipole antenna that was the source of the radiation. No details are given about the temperature of the rats' skins.
The aim of the study was to investigate the effect of the RFR on skin histology. Skin levels were assessed of MDA, which is an indicator of free radical generation. Hydroxyproline, an indicator of tissue fibrosis and lipid peroxidation, was also assessed, as were antioxidant enzymes, SOD, GSH-Px, and CAT.
MDA and hydroxyproline levels and activities of CAT and GSH-Px were increased significantly in the irradiated group compared to the control group and decreased significantly in the melatonin group. SOD activity was decreased significantly in the irradiated group and this decrease was not prevented by melatonin. The authors concluded that "rats irradiated with 900 MHz suffer from increased fibrosis and lipid peroxidation. Melatonin treatment can reduce the fibrosis and lipid peroxidation".
It should be noted that no details were given about the temperature levels in the skin of the rats.